CAS Science Team

Bio

Drug Discovery
The GIP and GLP-1 function shows promising results in treating cardiovascular and neurodegenerative conditions.
|Article
Emerging Science
Three categories of breakthroughs that have been awarded the Nobel Prize in Chemistry in the last forty years
|Article
Digital R&D
Why are there no FDA approved TBK1 (TANK-binding kinase) inhibitors on the market, despite the key role it plays in the pathophysiology of many diseases.
|Insights Report
Materials
Nanofibers, nanoplastics, and more are gaining research interest. See more nanotechnology breakthroughs through the lens of a CAS TrendScape analysis.
|Article
Emerging Science
Rare diseases are difficult to treat, diagnose, and identify. As such, researchers are spending more effort in better understanding and treating these illnesses.
|Insights Report
Digital R&D
Combining advanced technologies with human curation identifies emerging trends in nanotechnology research.
|Article
Sustainability
Recycling plastics can be challenging with traditional methods, leading to developments in chemical plastic recycling technology.
|Article
Materials
Biomedicine, batteries, and more could be revolutionized by carbon nanotubes. See the full range of their applications.
|Executive Summary
Materials
This detailed technical report, published in collaboration with Westlake University, discusses the biomaterials landscape and how this field is rapidly changing.
|Insights Report
Consumer Goods
Learn about the shift towards sustainable and natural ingredients in cosmetics, supported by data from the CAS Content Collection™.
|Article
Drug Discovery
Different types of antisense oligonucleotide therapies, such as exosomes and nanoparticles, offering new hope in genetic medicine.
|Article
Materials
Unlock the potential of nanotechnology. Explore breakthroughs and challenges in energy, biomedicine, and more in our executive summary.
|Insights Report
Materials
This biomaterials Insights Report explores eight key areas transforming healthcare with self-healing implants, targeted drug delivery, and more.
|Insights Report
Consumer Goods
Uncover the science behind sweeteners, their health impacts, R&D trends, and investment data.
|Executive Summary
Materials
Carbon nanotubes (CNTs) hold immense promise for batteries, composites, sensors, and more. Discover emerging trends on overcoming challenges and cutting edge applications.
|Article
Emerging Science
Biomarkers could help doctors catch cancer earlier, cure it more frequently, and perform treatments with fewer risks.
|Executive Summary
Sustainability
Recycling semiconductors was once a far-off dream. However, new research and technology shows that this could become reality.
|Article
Intellectual Property
See key insights on emerging RNA IP trends and possibilities for future innovations in this executive summary.
|Executive Summary
Emerging Science
As antimicrobial resistance becomes a larger problem, new approaches to battling infections are emerging.
|Executive Summary
Sustainability
See how new innovations like biorefineries, waste repurposing, and materials are reshaping the future of sustainable fertilizers.
|Infographic
Digital R&D
Discover how AI in the food industry is transforming production, innovation, and sustainability. Learn how AI can help you create smarter and more efficient food solutions.
|Article
Drug Discovery
Immunotherapy is advancing with new approaches like CAR-T cell therapy, antibody-drug conjugates, and even checkpoint inhibitors.
|Executive Summary
Emerging Science
Stay ahead of the latest scientific breakthroughs that are accelerating the landscape of innovation and will transform global science in 2024
|Article
Drug Discovery
The pharma industry is tackling major drug discovery challenges in several new ways. Have they been successful?
|Article
Sustainability
With the push towards increased sustainability, here are four ways coatings manufacturers are making use of renewable feedstock for their own products.
|Article
Drug Discovery
Covalent inhibitors were once avoided due to negative side effects, but new drugs have changed the landscape.
|Executive Summary
Biotechnology
Drugs created with covalent inhibitors are becoming more popular than other types, owing to their unique mechanism of action.
|Article
Drug Discovery
More than 100 antibody-drug conjugates are in clinical trials. These therapeutics combine the targeting abilities of antibodies with the power of chemotherapy to change cancer treatment.
|Executive Summary
Emerging Science
Today, OLEDs are appearing everywhere on phones, media players, portable gaming systems, lighting, and even car radios.
|Article
Emerging Science
It is surprising that the chemical synthesis of DNA has not won a Nobel prize because it transformed DNA synthesis from a specialized exploration into a widely used research, diagnostic, and forensic tool.
|Article
Emerging Science
Traditionally, many key benefits of a drug or pharmaceutical cannot be realized because of their poor solubility, high toxicity, or stability problems. However, the use of dendrimers as drug delivery vehicles can solve many of these problems.
|Article
Emerging Science
Today, OLEDs are appearing everywhere on phones, media players, portable gaming systems, lighting, and even car radios.
|Article
Emerging Science
While much of the world has already seen the impact that mRNA has had on vaccines for COVID-19, it may be time to recognize Dr. Katalin Karikó and Dr. Drew Weissman for their outstanding contributions to nucleoside modifications to suppress RNA immunogenicity on top of their pioneering work.
|Article
Emerging Science
Gut microbiome research has expanded exponentially in recent years, with fecal microbiota transplantation (FMT) at the forefront of this research.
|Article
Emerging Science
CAS scientists discuss overlooked ideas that have yet to win a Nobel Prize. From OLEDs and MOFs to mRNA therapeutics and more, these ideas have reshaped science and technology.
|Article
Intellectual Property
Incomplete prior art searches and analyses can lead to costly mistakes, leaving innovations and the value of intellectual property open to huge risk.
|Article
Intellectual Property
Patentability assessments in scientific industries come with significant challenges due to their complexity. However, CAS has tools designed to address these issues.
|Article
Emerging Science
CAS, the LaJolla Institute for Immunology, and Avidity Biosciences explore the convergence of biology and chemistry in emerging therapeutics for cancer, vaccines, and more.
|Article
Sustainability
With consumers changing their diets for personal and health reasons, innovation to increase quality and variety creates a diverse and competitive market.
|Article
Consumer Goods
Hero ingredients can help create more advanced and versatile formulations than ever before as consumers slim down their cosmetic routines.
|Article
Emerging Science
Chemistry is powering space exploration with rocket fuel and engine technologies. Discover the advantages and challenges of using LOX/LH2 as a propellant for the Artemis mission.
|Article
Sustainability
Catalysts have been enabling green chemistry with applications in many industries.
|Executive Summary
Biotechnology
Thanks to mRNA vaccines, which have revolutionized the fight against COVID-19, we can treat cancer by harnessing the power of the immune system.
|Article
Emerging Science
Biomaterials like hydrogels, lipid nanoparticles, and exosomes are reshaping the landscape of drug delivery, diagnosis, and therapeutics.
|Insights Report
Intellectual Property
Learn how leveraging patent tools and strategies can accelerate your path toward comprehensive searches and stronger insights.
|Article
Emerging Science
Research in anti-aging treatments has reached a pivotal point. How do new treatments, drugs, and clinical trials compare to time-tested practices?
|Executive Summary
Intellectual Property
Accelerate and improve the ROI of your IP and R&D initiatives by partnering with an industry and IP expert.
|Article
Sustainability
Microplastics have infiltrated our entire world, even down to the water we drink and food we eat. Researchers are looking at new ways to address them.
|Infographic
Sustainability
Graphene-based supercapacitor technologies are being levied for real-world applications as a battery alternative.
|Article
Drug Discovery
Induced-proximity target protein degradation (TPD) is a ground-breaking strategy in drug discovery that has emerged recently.
|Insights Report
Intellectual Property
A successful patent landscape analysis can maximize opportunities and de-risk your company's R&D program and other initiatives.
|Article
Emerging Science
mRNA vaccines created for COVID-19 have led to a slew of new research in mRNA therapeutics.
|Executive Summary
Digital R&D
What is dark data, and how can it be used to unlock data insights and accelerate innovation for R&D?
|Article
Biotechnology
Discover how advances in 3D printing materials and approaches have reshaped tissues and organ sourcing, drug delivery methods, and wound care.
|Infographic
Biotechnology
Investment in RNA has grown beyond vaccines. Cancer, infectious diseases, and even liver diseases have all been identified for RNA medicines.
|Infographic
Sustainability
Learn five ways to reduce waste and use biodegradable materials to develop sustainable sterile packaging options for medical devices.
|Article
Emerging Science
Learn how PEGylated lipid nanoparticles are used to deliver mRNA vaccines and other drugs, the immunogenicity concerns with vaccines, and emerging approaches on new designs to increase efficacy and safety.
|Journal Publication
Emerging Science
PEG immunogenicity is a challenge that affects the safety and efficacy of PEGylated lipid nanoparticles for drug delivery.
|Executive Summary
Emerging Science
Created in collaboration with Bayer AG, this report discusses the latest research on microbiome-based therapies, microbiota, probiotics, and the wide range of health conditions it can influence.
|Insights Report
Emerging Science
This publication in the ACS Chemical Neuroscience Journal details a landscape analysis of emerging trends in the gut microbiome space.
|Journal Publication
Sustainability
Microplastic pollution is a global problem due to their disruption of ecosystems and their ingestion by humans and animals.
|Executive Summary
Biotechnology
Exosomes are reshaping the future of drug delivery, therapeutics, and diagnostics. Learn about exosomes and the challenges with the technology.
|Infographic
Biotechnology
3D printing has major biomedical applications. See the new technologies that are reshaping personalized healthcare.
|Executive Summary
Synthetic Chemistry
CAS and the Chinese Academy of Sciences explore hidden connections and publication trends in synthetic organic chemistry.
|Insights Report
Synthetic Chemistry
This article, published in collaboration with the National Natural Science Foundation of China, the Chinese Academy of Sciences, and CAS, examines the state of global synthetic organic chemistry research with a focus on enzyme catalysis, photocatalysis, and green chemistry.
|Journal Publication
Sustainability
Agriculture and fertilizers have a sustainability problem. Understand emerging trends around reducing this industry's carbon emissions.
|Executive Summary
Safety
Incidents like the East Palestine chemical spill have led researchers to reevaluating the safety of transporting hazardous materials.
|Article
Biotechnology
The expansion of exosome research has led to significant clinical advancements, and new approaches to drug delivery and diagnostics.
|Executive Summary
Biotechnology
From prosthetic ears to artificial organs, learn about the latest trends and innovations in 3D printing in biomedicine.
|Insights Report
Biotechnology
The possibilities of 3D printing in biomedicine are nearly limitless, as evidenced by this journal publication.
|Journal Publication
Emerging Science
Stay ahead of the curve with the latest in emerging science and cutting-edge research that is accelerating the landscape of innovation in 2023.
|Article
Sustainability
Synthetic fertilizers ae valuable but leave a large carbon footprint. Sustainable fertilizers are an environmentally friendly alternative that is growing in interest.
|Insights Report
Sustainability
We analyze the scientific and patent trends on sustainable fertilizers in the CAS Content Collection to help scientists use new, more environmentally friendly sources.
|Journal Publication
Sustainability
Hydrogen fuel technology is being examined for powering electricity, heating, and transportation.
|Insights Report
Sustainability
educing, reusing, and recycling can improve fertilizer access, minimize environmental impact and dependence on finite resources, and lead to a circular bioeconomy.
|Article
Sustainability
Microplastics come from countless sources and have a large impact on the environment. Scientists are working hard to combat this growing problem.
|Insights Report
Sustainability
Methods to push back against the wave of microplastics that are poisoning the environment are in full swing.
|Journal Publication
Drug Discovery
The FDA can designate drug candidates as “breakthrough therapies” (breakthrough therapy designation or BTD) for certain drug candidates that demonstrate substantial improvement over available therapies on a clinically significant endpoint.
|Infographic
Biotechnology
Exosomes are nature’s lipid nanoparticles and their unique physical properties will unlock new applications in drug development, delivery and diagnostic applications in the future
|Insights Report
Biotechnology
Exosomes – nature's lipid nanoparticle, a rising star in drug delivery and diagnostics
|Journal Publication
Drug Discovery
Bioorthogonal chemistry is a set of methods that use the chemistry of non-native functional groups to analyze biology in living organisms.
|Journal Publication
Emerging Science
Timeline showing key reactions and applications culminating in 2022 Nobel Prize in Chemistry
|Infographic
Emerging Science
Learn about the basics of click chemistry and bioorthogonal chemistry that was recently awarded the 2022 Nobel Prize in Chemistry. Read about emerging trends, insights on publication trends, and future applications of bioorthogonal chemistry.
|Article
Drug Discovery
When mRNA (messenger RNA) vaccines are injected into a patient, tiny lipid vesicles transport mRNA molecules through the body fluids and merge with immune cells, called antigen-presenting cells (APCs).
|Video
Drug Discovery
Scientists are searching ways to stop the spread of COVID-19, and the ACE2 receptor is one of the most promising targets.
|Video
Digital R&D
Scientists at Bayer expand their understanding into new, useful chemistry by improving the predictive power of a synthesis planning model with scientist-curated reactions from CAS.
|Insights Report
Digital R&D
This whitepaper explores challenges and opportunities for worldwide patent offices as they seek to ensure sustainability and future growth. It focuses on the application of artificial intelligence-enabled workflow solutions to enhance productivity and patent quality.
|Insights Report
Drug Discovery
Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms.
|Insights Report
Sustainability
Learn more about the scientific challenges, emerging technologies, and the financial and environmental implications for recycling lithium ion batteries.
|Insights Report
Sustainability
With over 90% of the world’s plastics production requiring fossil fuels, bio-based polymers generated from renewable sources have substantial benefits over traditional plastics – from reducing CO2 emissions, increased biodegradability, and less dependence on fossil fuels. Learn more in our landscape
|Insights Report
Drug Discovery
This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.
|Insights Report
Drug Discovery
This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.
|Insights Report
Drug Discovery
Targeted protein degradation is a novel and quickly expanding drug discovery strategy. It is a new way of utilizing disease-causing proteins to attack severe illnesses, which has the potential to be used among more serious illnesses, such as cancer or neurodegenerative diseases.
|Journal Publication
Drug Discovery
Artificial intelligence (AI) and machine learning have been growing exponentially over the last decade, but how has the field of Chemistry evolved with this emerging trend?
|Insights Report
Drug Discovery
Lipid nanoparticles play critical roles in mRNA vaccines for treating COVID-19, but their use is not new. Read about past, present, and future opportunities.
|Insights Report
Drug Discovery
The use of RNA in therapeutics has the potential to revolutionize medicine. This white paper highlights the emerging trends in the industry.
|Insights Report
Drug Discovery
The last decade has seen a dramatic shift towards RNA-based medicine. Rapid success in developing lipid-RNA nanoparticles for COVID-19 mRNA vaccines, along with several approved drugs, has propelled RNA to the forefront of pharmaceutical research and development. Explore this revolutionary trend.
|Journal Publication
Sustainability
Many technologies have been researched with an eye toward enabling a hydrogen economy.
|Journal Publication
Drug Discovery
This white paper details the CAS Biomedical Knowledge Graph and shows how it was used in drug discovery for COVID-19.
|Insights Report
Sustainability
Most synthetic polymers are derived from fossil fuel resources, whose scarcity and imbalanced global distribution can affect plastics producers. Bio-based polymers, obtained from renewable biomass resources, have received wide attention in the past two decades.
|Journal Publication