Bio
Drug Discovery
Exploring how the GLP-1 function may provide benefits beyond weight loss and diabetes
The GIP and GLP-1 function shows promising results in treating cardiovascular and neurodegenerative conditions.
Emerging Science
Three paths to a Nobel Prize in chemistry
Three categories of breakthroughs that have been awarded the Nobel Prize in Chemistry in the last forty years
Digital R&D
Defining the path to TBK1 inhibition with QSAR modeling
Why are there no FDA approved TBK1 (TANK-binding kinase) inhibitors on the market, despite the key role it plays in the pathophysiology of many diseases.
Materials
Co-occurrence analysis spots nanotechnology breakthroughs
Nanofibers, nanoplastics, and more are gaining research interest. See more nanotechnology breakthroughs through the lens of a CAS TrendScape analysis.
Emerging Science
Rare diseases: Impact, landscape, and possibilities
Rare diseases are difficult to treat, diagnose, and identify. As such, researchers are spending more effort in better understanding and treating these illnesses.
Digital R&D
Identifying emerging trends in nanotechnology research
Combining advanced technologies with human curation identifies emerging trends in nanotechnology research.
Sustainability
Innovating the chemical recycling of plastics
Recycling plastics can be challenging with traditional methods, leading to developments in chemical plastic recycling technology.
Materials
Idea in brief: Emerging trends and future opportunities for carbon nanotubes
Biomedicine, batteries, and more could be revolutionized by carbon nanotubes. See the full range of their applications.
Materials
CAS and Westlake University publication on biomaterials: Full-length report
This detailed technical report, published in collaboration with Westlake University, discusses the biomaterials landscape and how this field is rapidly changing.
Consumer Goods
Evolving beauty: The rise of sustainable and natural ingredients for cosmetics
Learn about the shift towards sustainable and natural ingredients in cosmetics, supported by data from the CAS Content Collection™.
Drug Discovery
Types of antisense oligonucleotides: Advancing therapeutic frontiers
Different types of antisense oligonucleotide therapies, such as exosomes and nanoparticles, offering new hope in genetic medicine.
Materials
How nanotechnology delivers massive change in energy, biomedicine and more.
Unlock the potential of nanotechnology. Explore breakthroughs and challenges in energy, biomedicine, and more in our executive summary.
Materials
The material difference: How biomaterials are reshaping medicine and patient outcomes
This biomaterials Insights Report explores eight key areas transforming healthcare with self-healing implants, targeted drug delivery, and more.
Consumer Goods
Unraveling the science behind artificial sweeteners
Uncover the science behind sweeteners, their health impacts, R&D trends, and investment data.
Materials
From batteries to drug delivery: Emerging applications of carbon nanotubes
Carbon nanotubes (CNTs) hold immense promise for batteries, composites, sensors, and more. Discover emerging trends on overcoming challenges and cutting edge applications.
Emerging Science
16 billion reasons for hope: How biomarkers are reshaping cancer outcomes
Biomarkers could help doctors catch cancer earlier, cure it more frequently, and perform treatments with fewer risks.
Sustainability
Science fact vs. fiction: Can we recycle semiconductors?
Recycling semiconductors was once a far-off dream. However, new research and technology shows that this could become reality.
Intellectual Property
IP trends and opportunities: RNA therapeutics
See key insights on emerging RNA IP trends and possibilities for future innovations in this executive summary.
Emerging Science
Idea in brief: battling antibiotic resistant infections
As antimicrobial resistance becomes a larger problem, new approaches to battling infections are emerging.
Sustainability
Infographic: Sustainable crops start with green(er) fertilizers
See how new innovations like biorefineries, waste repurposing, and materials are reshaping the future of sustainable fertilizers.
Digital R&D
Embracing the future of AI in the food industry
Discover how AI in the food industry is transforming production, innovation, and sustainability. Learn how AI can help you create smarter and more efficient food solutions.
Drug Discovery
R&D Insight: Unique views into immuno-oncology
Immunotherapy is advancing with new approaches like CAR-T cell therapy, antibody-drug conjugates, and even checkpoint inhibitors.
Emerging Science
Scientific breakthroughs: 2024 emerging trends to watch
Stay ahead of the latest scientific breakthroughs that are accelerating the landscape of innovation and will transform global science in 2024
Drug Discovery
Dealing with the challenges of drug discovery
The pharma industry is tackling major drug discovery challenges in several new ways. Have they been successful?
Sustainability
Four uses for renewable feedstock in sustainable coatings
With the push towards increased sustainability, here are four ways coatings manufacturers are making use of renewable feedstock for their own products.
Drug Discovery
R&D insights: The covalent inhibitor revolution
Covalent inhibitors were once avoided due to negative side effects, but new drugs have changed the landscape.
Biotechnology
The rise of covalent inhibitors in strategic therapeutic design
Drugs created with covalent inhibitors are becoming more popular than other types, owing to their unique mechanism of action.
Drug Discovery
R&D insights: Antibody-drug conjugates
More than 100 antibody-drug conjugates are in clinical trials. These therapeutics combine the targeting abilities of antibodies with the power of chemotherapy to change cancer treatment.
Emerging Science
How OLEDs could light up the Nobel Prize
Today, OLEDs are appearing everywhere on phones, media players, portable gaming systems, lighting, and even car radios.
Emerging Science
Synthesizing DNA unlocked the secrets of life
It is surprising that the chemical synthesis of DNA has not won a Nobel prize because it transformed DNA synthesis from a specialized exploration into a widely used research, diagnostic, and forensic tool.
Emerging Science
Are dendrimers, nanoscience, and supramolecular chemistry ready for a Nobel Prize?
Traditionally, many key benefits of a drug or pharmaceutical cannot be realized because of their poor solubility, high toxicity, or stability problems. However, the use of dendrimers as drug delivery vehicles can solve many of these problems.
Emerging Science
The case for the Nobel Prize with metal-organic frameworks
Today, OLEDs are appearing everywhere on phones, media players, portable gaming systems, lighting, and even car radios.
Emerging Science
Nobel worthy: mRNA vaccines beyond COVID
While much of the world has already seen the impact that mRNA has had on vaccines for COVID-19, it may be time to recognize Dr. Katalin Karikó and Dr. Drew Weissman for their outstanding contributions to nucleoside modifications to suppress RNA immunogenicity on top of their pioneering work.
Emerging Science
Gut microbiome advances are reshaping future outcomes
Gut microbiome research has expanded exponentially in recent years, with fecal microbiota transplantation (FMT) at the forefront of this research.
Emerging Science
Quantum dots win the 2023 Nobel Prize for Chemistry
CAS scientists discuss overlooked ideas that have yet to win a Nobel Prize. From OLEDs and MOFs to mRNA therapeutics and more, these ideas have reshaped science and technology.
Intellectual Property
Prior art search and analysis for scientific IP strategies
Incomplete prior art searches and analyses can lead to costly mistakes, leaving innovations and the value of intellectual property open to huge risk.
Intellectual Property
Navigating patentability assessments in scientific industries
Patentability assessments in scientific industries come with significant challenges due to their complexity. However, CAS has tools designed to address these issues.
Emerging Science
CAS Symposium Explores Convergence of Biology and Chemistry in Emerging Therapeutics
CAS, the LaJolla Institute for Immunology, and Avidity Biosciences explore the convergence of biology and chemistry in emerging therapeutics for cancer, vaccines, and more.
Sustainability
Going green with plant-based meat sustainability
With consumers changing their diets for personal and health reasons, innovation to increase quality and variety creates a diverse and competitive market.
Consumer Goods
Multifunctional cosmetics: Developing a product that ‘does it all’
Hero ingredients can help create more advanced and versatile formulations than ever before as consumers slim down their cosmetic routines.
Emerging Science
Mars is calling, but how will Artemis fuel the journey?
Chemistry is powering space exploration with rocket fuel and engine technologies. Discover the advantages and challenges of using LOX/LH2 as a propellant for the Artemis mission.
Sustainability
R&D insights: Sustainable catalysts for the future
Catalysts have been enabling green chemistry with applications in many industries.
Biotechnology
From fighting viruses to tackling tumors: Harnessing mRNA vaccines to treat cancer
Thanks to mRNA vaccines, which have revolutionized the fight against COVID-19, we can treat cancer by harnessing the power of the immune system.
Emerging Science
Top 10 emerging trends in biomaterials
Biomaterials like hydrogels, lipid nanoparticles, and exosomes are reshaping the landscape of drug delivery, diagnosis, and therapeutics.
Intellectual Property
Patent searching: Going beyond the basics to increase efficiency
Learn how leveraging patent tools and strategies can accelerate your path toward comprehensive searches and stronger insights.
Emerging Science
Executive summary: What’s next in anti-aging treatments?
Research in anti-aging treatments has reached a pivotal point. How do new treatments, drugs, and clinical trials compare to time-tested practices?
Intellectual Property
The why’s and how’s of partnerships in scientific patent searching
Accelerate and improve the ROI of your IP and R&D initiatives by partnering with an industry and IP expert.
Sustainability
Infographic: What can be done about microplastics?
Microplastics have infiltrated our entire world, even down to the water we drink and food we eat. Researchers are looking at new ways to address them.
Sustainability
Supercapacitor technologies: Is graphene finally living up to its full potential?
Graphene-based supercapacitor technologies are being levied for real-world applications as a battery alternative.
Drug Discovery
Targeted protein degradation and induced proximity: Molecular glues landscape in drug discovery
Induced-proximity target protein degradation (TPD) is a ground-breaking strategy in drug discovery that has emerged recently.
Intellectual Property
Maximize opportunities with a patent landscape analysis
A successful patent landscape analysis can maximize opportunities and de-risk your company's R&D program and other initiatives.
Emerging Science
Top emerging trends in mRNA therapeutics
mRNA vaccines created for COVID-19 have led to a slew of new research in mRNA therapeutics.
Digital R&D
Unlocking the power of dark data in chemistry R&D: Strategies for success
What is dark data, and how can it be used to unlock data insights and accelerate innovation for R&D?
Biotechnology
Infographic: 3D printing is reshaping the future of biomedicine
Discover how advances in 3D printing materials and approaches have reshaped tissues and organ sourcing, drug delivery methods, and wound care.
Biotechnology
Infographic: Top investment trends for RNA and the outlook ahead
Investment in RNA has grown beyond vaccines. Cancer, infectious diseases, and even liver diseases have all been identified for RNA medicines.
Sustainability
Five ways to achieve sustainable medical packaging
Learn five ways to reduce waste and use biodegradable materials to develop sustainable sterile packaging options for medical devices.
Emerging Science
Peer-reviewed journal: PEG immunogenicity and vaccine safety
Learn how PEGylated lipid nanoparticles are used to deliver mRNA vaccines and other drugs, the immunogenicity concerns with vaccines, and emerging approaches on new designs to increase efficacy and safety.
Emerging Science
What you need to know about PEG immunogenicity
PEG immunogenicity is a challenge that affects the safety and efficacy of PEGylated lipid nanoparticles for drug delivery.
Emerging Science
Recognizing the potential of the gut microbiome
Created in collaboration with Bayer AG, this report discusses the latest research on microbiome-based therapies, microbiota, probiotics, and the wide range of health conditions it can influence.
Emerging Science
Peer reviewed publication: New discoveries on emerging microbiome trends
This publication in the ACS Chemical Neuroscience Journal details a landscape analysis of emerging trends in the gut microbiome space.
Sustainability
R&D Insights: Tiny microplastics with massive implications
Microplastic pollution is a global problem due to their disruption of ecosystems and their ingestion by humans and animals.
Biotechnology
Exosomes, the rising star of therapeutics: Infographic
Exosomes are reshaping the future of drug delivery, therapeutics, and diagnostics. Learn about exosomes and the challenges with the technology.
Biotechnology
R&D Insights: 3D printing in biomedical applications
3D printing has major biomedical applications. See the new technologies that are reshaping personalized healthcare.
Synthetic Chemistry
Top emerging trends in synthetic organic chemistry
CAS and the Chinese Academy of Sciences explore hidden connections and publication trends in synthetic organic chemistry.
Synthetic Chemistry
Synthetic organic chemistry: Peer-reviewed landscape publication
This article, published in collaboration with the National Natural Science Foundation of China, the Chinese Academy of Sciences, and CAS, examines the state of global synthetic organic chemistry research with a focus on enzyme catalysis, photocatalysis, and green chemistry.
Sustainability
R&D Insights: Sustainable agriculture and fertilizer production
Agriculture and fertilizers have a sustainability problem. Understand emerging trends around reducing this industry's carbon emissions.
Safety
The science behind dioxins, vinyl chloride, and proven remediations
Incidents like the East Palestine chemical spill have led researchers to reevaluating the safety of transporting hazardous materials.
Biotechnology
R&D Insights: Exosomes in drug delivery and diagnostics
The expansion of exosome research has led to significant clinical advancements, and new approaches to drug delivery and diagnostics.
Biotechnology
From polymers to prosthetics: the growth of 3D printing in biomedicine
From prosthetic ears to artificial organs, learn about the latest trends and innovations in 3D printing in biomedicine.
Biotechnology
Explore biomedicine’s 3D printing scientific journal review
The possibilities of 3D printing in biomedicine are nearly limitless, as evidenced by this journal publication.
Emerging Science
Top scientific breakthroughs and emerging trends for 2023
Stay ahead of the curve with the latest in emerging science and cutting-edge research that is accelerating the landscape of innovation in 2023.
Sustainability
Innovation in sustainable fertilizer production
Synthetic fertilizers ae valuable but leave a large carbon footprint. Sustainable fertilizers are an environmentally friendly alternative that is growing in interest.
Sustainability
Scientific review on sustainable fertilizers
We analyze the scientific and patent trends on sustainable fertilizers in the CAS Content Collection to help scientists use new, more environmentally friendly sources.
Sustainability
Hydrogen fuel-Insights into a growing market
Hydrogen fuel technology is being examined for powering electricity, heating, and transportation.
Sustainability
Reduce, reuse, recycle: the path to sustainable agriculture
educing, reusing, and recycling can improve fertilizer access, minimize environmental impact and dependence on finite resources, and lead to a circular bioeconomy.
Sustainability
Microplastics: Tackling the invisible enemy
Microplastics come from countless sources and have a large impact on the environment. Scientists are working hard to combat this growing problem.
Sustainability
Scientific review on microplastics pollution
Methods to push back against the wave of microplastics that are poisoning the environment are in full swing.
Drug Discovery
Expedited FDA designation of breakthrough therapy
The FDA can designate drug candidates as “breakthrough therapies” (breakthrough therapy designation or BTD) for certain drug candidates that demonstrate substantial improvement over available therapies on a clinically significant endpoint.
Biotechnology
Exosomes: Reshaping drug delivery and diagnostics
Exosomes are nature’s lipid nanoparticles and their unique physical properties will unlock new applications in drug development, delivery and diagnostic applications in the future
Biotechnology
Exosomes – nature's lipid nanoparticle, a rising star in drug delivery and diagnostics
Exosomes – nature's lipid nanoparticle, a rising star in drug delivery and diagnostics
Drug Discovery
Bioorthogonal chemistry and its applications
Bioorthogonal chemistry is a set of methods that use the chemistry of non-native functional groups to analyze biology in living organisms.
Emerging Science
Infographic - Bioorthogonal Chemistry's Path to the Nobel Prize
Timeline showing key reactions and applications culminating in 2022 Nobel Prize in Chemistry
Emerging Science
Key insights on click chemistry and bioorthogonal chemistry
Learn about the basics of click chemistry and bioorthogonal chemistry that was recently awarded the 2022 Nobel Prize in Chemistry. Read about emerging trends, insights on publication trends, and future applications of bioorthogonal chemistry.
Drug Discovery
How mRNA COVID-19 vaccines work to fight COVID-19
When mRNA (messenger RNA) vaccines are injected into a patient, tiny lipid vesicles transport mRNA molecules through the body fluids and merge with immune cells, called antigen-presenting cells (APCs).
Drug Discovery
Targeting ACE2 for treatments of COVID-19
Scientists are searching ways to stop the spread of COVID-19, and the ACE2 receptor is one of the most promising targets.
Digital R&D
Predicting new chemistry: Impact of high-quality training data on prediction of reaction outcomes
Scientists at Bayer expand their understanding into new, useful chemistry by improving the predictive power of a synthesis planning model with scientist-curated reactions from CAS.
Digital R&D
Addressing sustainability of the global patent system: the role of AI in enhancing productivity
This whitepaper explores challenges and opportunities for worldwide patent offices as they seek to ensure sustainability and future growth. It focuses on the application of artificial intelligence-enabled workflow solutions to enhance productivity and patent quality.
Drug Discovery
Bioorthogonal chemistry: A review of its diverse applications in science and medicine
Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms.
Sustainability
Lithium ion battery recycling
Learn more about the scientific challenges, emerging technologies, and the financial and environmental implications for recycling lithium ion batteries.
Sustainability
Bio-based Polymers: A Green Alternative to Traditional Plastics
With over 90% of the world’s plastics production requiring fossil fuels, bio-based polymers generated from renewable sources have substantial benefits over traditional plastics – from reducing CO2 emissions, increased biodegradability, and less dependence on fossil fuels. Learn more in our landscape
Drug Discovery
Accelerating discovery: COVID-19 vaccine breakthroughs and their future impact
This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.
Drug Discovery
Accelerating Discovery: COVID-19 Vaccine Breakthroughs and their Future Impact
This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.
Drug Discovery
How molecular glues are connecting targeted protein degradation to the clinic
Targeted protein degradation is a novel and quickly expanding drug discovery strategy. It is a new way of utilizing disease-causing proteins to attack severe illnesses, which has the potential to be used among more serious illnesses, such as cancer or neurodegenerative diseases.
Drug Discovery
The Landscape of Artificial Intelligence in Chemistry and Opportunities for Growth
Artificial intelligence (AI) and machine learning have been growing exponentially over the last decade, but how has the field of Chemistry evolved with this emerging trend?
Drug Discovery
Lipid Nanoparticles: Past, Present, and Future Opportunities
Lipid nanoparticles play critical roles in mRNA vaccines for treating COVID-19, but their use is not new. Read about past, present, and future opportunities.
Drug Discovery
RNA-Derived Medicines: A review of the research trends and developments
The use of RNA in therapeutics has the potential to revolutionize medicine. This white paper highlights the emerging trends in the industry.
Drug Discovery
The progress and promise of RNA medicine─An arsenal of targeted treatments
The last decade has seen a dramatic shift towards RNA-based medicine. Rapid success in developing lipid-RNA nanoparticles for COVID-19 mRNA vaccines, along with several approved drugs, has propelled RNA to the forefront of pharmaceutical research and development. Explore this revolutionary trend.
Sustainability
A review of materials research for a green hydrogen economy
Many technologies have been researched with an eye toward enabling a hydrogen economy.
Drug Discovery
Knowledge graphs accelerate COVID-19 therapies
This white paper details the CAS Biomedical Knowledge Graph and shows how it was used in drug discovery for COVID-19.
Sustainability
Bio-based polymers as an alternative to fossil fuel plastics
Most synthetic polymers are derived from fossil fuel resources, whose scarcity and imbalanced global distribution can affect plastics producers. Bio-based polymers, obtained from renewable biomass resources, have received wide attention in the past two decades.