CAS Science Team

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Digital R&D
Why are there no FDA approved TBK1 (TANK-binding kinase) inhibitors on the market, despite the key role it plays in the pathophysiology of many diseases.
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Materials
Biomedicine, batteries, and more could be revolutionized by carbon nanotubes. See the full range of their applications.
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Materials
Este relatório técnico detalhado, publicado em colaboração com a Westlake University, discute o cenário dos biomateriais e como esse campo está mudando rapidamente.
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Consumer Goods
Learn about the shift towards sustainable and natural ingredients in cosmetics, supported by data from the CAS Content Collection™.
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Drug Discovery
Different types of antisense oligonucleotide therapies, such as exosomes and nanoparticles, offering new hope in genetic medicine.
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Materials
Unlock the potential of nanotechnology. Explore breakthroughs and challenges in energy, biomedicine, and more in our executive summary.
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Materials
This biomaterials Insights Report explores eight key areas transforming healthcare with self-healing implants, targeted drug delivery, and more.
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Consumer Goods
Descubra a ciência por trás dos adoçantes, seus impactos na saúde, tendências de P&D e dados de investimento.
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Materials
Carbon nanotubes (CNTs) hold immense promise for batteries, composites, sensors, and more. Discover emerging trends on overcoming challenges and cutting edge applications.
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Emerging Science
Biomarkers could help doctors catch cancer earlier, cure it more frequently, and perform treatments with fewer risks.
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Sustainability
Recycling semiconductors was once a far-off dream. However, new research and technology shows that this could become reality.
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Intellectual Property
See key insights on emerging RNA IP trends and possibilities for future innovations in this executive summary.
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Emerging Science
As antimicrobial resistance becomes a larger problem, new approaches to battling infections are emerging.
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Intellectual Property
The landscape of exosomes has become highly competitive. See all the recent investments, innovations, and commercial opportunities.
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Digital R&D
Discover how AI in the food industry is transforming production, innovation, and sustainability. Learn how AI can help you create smarter and more efficient food solutions.
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Drug Discovery
Immunotherapy is advancing with new approaches like CAR-T cell therapy, antibody-drug conjugates, and even checkpoint inhibitors.
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Emerging Science
Stay ahead of the latest scientific breakthroughs that are accelerating the landscape of innovation and will transform global science in 2024
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Drug Discovery
The pharma industry is tackling major drug discovery challenges in several new ways. Have they been successful?
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Sustainability
With the push towards increased sustainability, here are four ways coatings manufacturers are making use of renewable feedstock for their own products.
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Drug Discovery
Covalent inhibitors were once avoided due to negative side effects, but new drugs have changed the landscape.
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Biotechnology
Drugs created with covalent inhibitors are becoming more popular than other types, owing to their unique mechanism of action.
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Drug Discovery
More than 100 antibody-drug conjugates are in clinical trials. These therapeutics combine the targeting abilities of antibodies with the power of chemotherapy to change cancer treatment.
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Emerging Science
CAS scientists discuss overlooked ideas that have yet to win a Nobel Prize. From OLEDs and MOFs to mRNA therapeutics and more, these ideas have reshaped science and technology.
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Intellectual Property
Incomplete prior art searches and analyses can lead to costly mistakes, leaving innovations and the value of intellectual property open to huge risk.
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Intellectual Property
Patentability assessments in scientific industries come with significant challenges due to their complexity. However, CAS has tools designed to address these issues.
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Emerging Science
CAS, the LaJolla Institute for Immunology, and Avidity Biosciences explore the convergence of biology and chemistry in emerging therapeutics for cancer, vaccines, and more.
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Sustainability
With consumers changing their diets for personal and health reasons, innovation to increase quality and variety creates a diverse and competitive market.
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Consumer Goods
Hero ingredients can help create more advanced and versatile formulations than ever before as consumers slim down their cosmetic routines.
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Emerging Science
Chemistry is powering space exploration with rocket fuel and engine technologies. Discover the advantages and challenges of using LOX/LH2 as a propellant for the Artemis mission.
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Sustainability
Catalysts have been enabling green chemistry with applications in many industries.
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Biotechnology
Thanks to mRNA vaccines, which have revolutionized the fight against COVID-19, we can treat cancer by harnessing the power of the immune system.
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Emerging Science
Biomaterials like hydrogels, lipid nanoparticles, and exosomes are reshaping the landscape of drug delivery, diagnosis, and therapeutics.
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Intellectual Property
Learn how leveraging patent tools and strategies can accelerate your path toward comprehensive searches and stronger insights.
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Emerging Science
Research in anti-aging treatments has reached a pivotal point. How do new treatments, drugs, and clinical trials compare to time-tested practices?
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Intellectual Property
Accelerate and improve the ROI of your IP and R&D initiatives by partnering with an industry and IP expert.
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Sustainability
Microplastics have infiltrated our entire world, even down to the water we drink and food we eat. Researchers are looking at new ways to address them.
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Sustainability
Graphene-based supercapacitor technologies are being levied for real-world applications as a battery alternative.
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Drug Discovery
Induced-proximity target protein degradation (TPD) is a ground-breaking strategy in drug discovery that has emerged recently.
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Intellectual Property
A successful patent landscape analysis can maximize opportunities and de-risk your company's R&D program and other initiatives.
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Emerging Science
mRNA vaccines created for COVID-19 have led to a slew of new research in mRNA therapeutics.
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Digital R&D
What is dark data, and how can it be used to unlock data insights and accelerate innovation for R&D?
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Biotechnology
Discover how advances in 3D printing materials and approaches have reshaped tissues and organ sourcing, drug delivery methods, and wound care.
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Biotechnology
Investment in RNA has grown beyond vaccines. Cancer, infectious diseases, and even liver diseases have all been identified for RNA medicines.
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Sustainability
Learn five ways to reduce waste and use biodegradable materials to develop sustainable sterile packaging options for medical devices.
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Emerging Science
Learn how PEGylated lipid nanoparticles are used to deliver mRNA vaccines and other drugs, the immunogenicity concerns with vaccines, and emerging approaches on new designs to increase efficacy and safety.
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Emerging Science
PEG immunogenicity is a challenge that affects the safety and efficacy of PEGylated lipid nanoparticles for drug delivery.
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Emerging Science
Created in collaboration with Bayer AG, this report discusses the latest research on microbiome-based therapies, microbiota, probiotics, and the wide range of health conditions it can influence.
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Emerging Science
This publication in the ACS Chemical Neuroscience Journal details a landscape analysis of emerging trends in the gut microbiome space.
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Sustainability
Microplastic pollution is a global problem due to their disruption of ecosystems and their ingestion by humans and animals.
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Biotechnology
Exosomes are reshaping the future of drug delivery, therapeutics, and diagnostics. Learn about exosomes and the challenges with the technology.
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Biotechnology
3D printing has major biomedical applications. See the new technologies that are reshaping personalized healthcare.
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Synthetic Chemistry
CAS and the Chinese Academy of Sciences explore hidden connections and publication trends in synthetic organic chemistry.
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Synthetic Chemistry
This article, published in collaboration with the National Natural Science Foundation of China, the Chinese Academy of Sciences, and CAS, examines the state of global synthetic organic chemistry research with a focus on enzyme catalysis, photocatalysis, and green chemistry.
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Sustainability
Agriculture and fertilizers have a sustainability problem. Understand emerging trends around reducing this industry's carbon emissions.
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Safety
Incidents like the East Palestine chemical spill have led researchers to reevaluating the safety of transporting hazardous materials.
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Biotechnology
The expansion of exosome research has led to significant clinical advancements, and new approaches to drug delivery and diagnostics.
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Biotechnology
From prosthetic ears to artificial organs, learn about the latest trends and innovations in 3D printing in biomedicine.
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Biotechnology
The possibilities of 3D printing in biomedicine are nearly limitless, as evidenced by this journal publication.
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Emerging Science
Stay ahead of the curve with the latest in emerging science and cutting-edge research that is accelerating the landscape of innovation in 2023.
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Sustainability
Synthetic fertilizers ae valuable but leave a large carbon footprint. Sustainable fertilizers are an environmentally friendly alternative that is growing in interest.
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Sustainability
We analyze the scientific and patent trends on sustainable fertilizers in the CAS Content Collection to help scientists use new, more environmentally friendly sources.
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Sustainability
Hydrogen fuel technology is being examined for powering electricity, heating, and transportation.
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Sustainability
Explore the path to sustainable agriculture and learn about the key role it plays in global food production. Discover how reducing, reusing, and recycling can improve fertilizer access, minimize environmental impact and dependence on finite resources, and lead to a circular bioeconomy. Learn about the latest innovations in sustainable agriculture, including smart nano-fertilizers, biorefineries, and biochar, and see how they can be used to harness the nutrient content of waste products to bolster food production and protect the environment.
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Sustainability
Microplastics come from countless sources and have a large impact on the environment. Scientists are working hard to combat this growing problem.
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Sustainability
Methods to push back against the wave of microplastics that are poisoning the environment are in full swing.
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Drug Discovery
The FDA can designate drug candidates as “breakthrough therapies” (breakthrough therapy designation or BTD) for certain drug candidates that demonstrate substantial improvement over available therapies on a clinically significant endpoint.
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Biotechnology
Exosomes are nature’s lipid nanoparticles and their unique physical properties will unlock new applications in drug development, delivery and diagnostic applications in the future
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Biotechnology
Exosomes – nature's lipid nanoparticle, a rising star in drug delivery and diagnostics
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Drug Discovery
Bioorthogonal chemistry is a set of methods that use the chemistry of non-native functional groups to analyze biology in living organisms.
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Emerging Science
Timeline showing key reactions and applications culminating in 2022 Nobel Prize in Chemistry
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Emerging Science
Learn about the basics of click chemistry and bioorthogonal chemistry that was recently awarded the 2022 Nobel Prize in Chemistry. Read about emerging trends, insights on publication trends, and future applications of bioorthogonal chemistry.
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Drug Discovery
When mRNA (messenger RNA) vaccines are injected into a patient, tiny lipid vesicles transport mRNA molecules through the body fluids and merge with immune cells, called antigen-presenting cells (APCs).
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Drug Discovery
Scientists are searching ways to stop the spread of COVID-19, and the ACE2 receptor is one of the most promising targets.
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Digital R&D
Scientists at Bayer expand their understanding into new, useful chemistry by improving the predictive power of a synthesis planning model with scientist-curated reactions from CAS.
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Digital R&D
This whitepaper explores challenges and opportunities for worldwide patent offices as they seek to ensure sustainability and future growth. It focuses on the application of artificial intelligence-enabled workflow solutions to enhance productivity and patent quality.
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Drug Discovery
Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms.
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Sustainability
Learn more about the scientific challenges, emerging technologies, and the financial and environmental implications for recycling lithium ion batteries.
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Sustainability
With over 90% of the world’s plastics production requiring fossil fuels, bio-based polymers generated from renewable sources have substantial benefits over traditional plastics – from reducing CO2 emissions, increased biodegradability, and less dependence on fossil fuels. Learn more in our landscape
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Drug Discovery
This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.
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Drug Discovery
This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.
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Drug Discovery
Targeted protein degradation is a novel and quickly expanding drug discovery strategy. It is a new way of utilizing disease-causing proteins to attack severe illnesses, which has the potential to be used among more serious illnesses, such as cancer or neurodegenerative diseases.
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Drug Discovery
Artificial intelligence (AI) and machine learning have been growing exponentially over the last decade, but how has the field of Chemistry evolved with this emerging trend?
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Drug Discovery
Lipid nanoparticles play critical roles in mRNA vaccines for treating COVID-19, but their use is not new. Read about past, present, and future opportunities.
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Drug Discovery
The use of RNA in therapeutics has the potential to revolutionize medicine. This white paper highlights the emerging trends in the industry.
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Drug Discovery
The last decade has seen a dramatic shift towards RNA-based medicine. Rapid success in developing lipid-RNA nanoparticles for COVID-19 mRNA vaccines, along with several approved drugs, has propelled RNA to the forefront of pharmaceutical research and development. Explore this revolutionary trend.
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Sustainability
Many technologies have been researched with an eye toward enabling a hydrogen economy.
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Drug Discovery
This white paper details the CAS Biomedical Knowledge Graph and shows how it was used in drug discovery for COVID-19.
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Sustainability
Most synthetic polymers are derived from fossil fuel resources, whose scarcity and imbalanced global distribution can affect plastics producers. Bio-based polymers, obtained from renewable biomass resources, have received wide attention in the past two decades.
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Sustainability
While human capabilities have only increased due to recent technological and medical advances, they have significantly contributed to the release of around 830 gigatons of CO2 into the atmosphere in just the last 30 years alone.
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Biotechnology
It turns out that these intrinsically disordered proteins may be the key to better overcoming diseases in neurodegeneration, diabetes, cardiovascular disease, amyloidosis, genetic diseases, and cancer.
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Sustainability
Learn more about carbon capture, storage, and reduction in our landscape view of this emerging research with unique insights.
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Sustainability
Lithium-ion batteries (LIBs) are commonly used in a variety of consumer products, including cellular phones, laptop computers, and more recently, electric and hybrid vehicles.
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Sustainability
As the production and usage of lithium-ion batteries (LIBs) has increased exponentially, their manufacturing and disposal have become subjects of political and environmental concerns.
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Drug Discovery
The COVID-19 pandemic has motivated researchers across the globe to find effective drugs and therapeutics for treating the disease.
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Drug Discovery
Nos últimos anos, a aplicação da IA à química cresceu rapidamente. Embora tenha havido inúmeras publicidades sobre a IA usada dessa maneira, não houve muita análise aprofundada sobre seu uso e desenvolvimento no campo da química.
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Drug Discovery
Lipid nanoparticles (LNPs) have emerged as promising vehicles to deliver a variety of therapeutics in the pharmaceutical industry. Liposomal drugs, based on an earlier version of LNPs, have already been approved and applied to medical practice.
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Drug Discovery
This report reviews Covid-19 vaccine research, compares the underlying technologies, the use of adjuvants and delivery systems in their application, and provides a perspective on their future direction.
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Safety
This in-depth CAS Insights Report discusses the chemical properties of ammonium nitrate, its hazards and safety rules, and provides a useful resource for those involved in the handling and storage of this compound.
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Drug Discovery
Artificial Intelligence may be hot right now, but the smart money is investing in data. See how CAS solutions can help.
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Drug Discovery
To identify potential anti-SARS-CoV-2 therapeutics, CAS scientists are building machine-learning predictive models to identify novel drug candidates for the viral targets 3 chymotrypsin-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp).
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